Onset of Paranoid Delusions After Addition of Topiramate for Seizure Disorder Treatment: A Case Report

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Sir: Incidence of psychosis during initial clinical trials of topiramate was reported as 0.8%, not significantly different from placebo.1 Auditory hallucinations, aggressive and suicidal thoughts, and paranoid delusions have been infrequently reported after initiation of topiramate.1,2 Although studies indicate that topiramate is generally well tolerated, neuropsychiatric side effects have been reported, including cognitive disturbances, confusion, psychomotor slowing, concentration problems, memory difficulties, depression, and mood disturbances.3

Prim Care Companion J Clin Psychiatry 2007;9(5):397-398 [letter]