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Tardive Dystonia and Ziprasidone: A Case Report

Prim Care Companion J Clin Psychiatry 2008;10(1):71-72 [letter]

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Sir: Ziprasidone is an atypical antipsychotic with higher affinity for human serotonin-2A (5-HT2A) receptors than dopamine-2 (D2) receptors. It is reported to have minimal extrapyramidal side effects similar to that of placebo.1 However, there are reports of acute dystonia with ziprasidone.2,3 A MEDLINE/PubMed search using keywords dystonia and ziprasidone revealed no published reports of tardive dystonia with ziprasidone.