Residual Symptoms in Major Depressive Disorder: Prevalence, Effects, and Management



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Patients with major depressive disorder (MDD) who have responded to or remitted from antidepressant treatment frequently have persistent residual symptoms (eg, fatigue, sleep problems, cognitive symptoms) that interfere with their functioning and quality of life and significantly increase the risk of relapse. Clinicians need to systematically evaluate for all depressive symptoms at baseline, so that some are not missed and the individual patient’s symptoms can be tracked across all phases of treatment. Developing a list of target problems that the patient would like to see improve is a helpful tool in this process.

From the Depression Treatment Research Center and the Department of Psychiatry, Rush University Medical Center, Chicago, Illinois (Dr Zajecka); Departments of Psychiatry and Obstetrics and the Institute for Wome’s Health, Virginia Commonwealth University, Richmond (Dr Kornstein); and the Departments of Psychiatry and Cellular and Molecular Medicine, University of Ottawa, and the Mood Disorders Research Unit, University of Ottawa Institute of Mental Health Research, Royal Ottawa Mental Health Centre, Ottawa, Ontario, Canada (Dr Blier).

J Clin Psychiatry 2013;74(4):407–414