Psychotic Exacerbation Following Subcutaneous Leuprolide in a Male Patient With Previous History of Schizophrenia

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To the Editor: Leuprolide acetate is a synthetic analog of naturally occurring gonadotropin-releasing hormone (GnRH) and, when given continuously, inhibits pituitary gonadotropin secretion and suppresses testicular and ovarian steroidogenesis. Leuprolide acetate is indicated for the palliative treatment of advanced prostate cancer and is available as a 1-month, 3-month, 4-month, and 6-month subcutaneous injection. In males, administration of leuprolide acetate results in testosterone levels below castrate threshold (< 50 ng/dL), with this decrease occurring within 2 to 4 weeks after initiation of treatment.' ‹