Cognitive Impairment and Functional Outcome
in Schizophrenia and Bipolar Disorder
impairment in schizophrenia and that in bipolar disorder share some
similarities. However, more literature exists on cognitive impairment in
schizophrenia than in bipolar disorder. The NIMH Measurement and Treatment
Research to Improve Cognition in Schizophrenia (MATRICS) Initiative has identified several cognitive domains that are dysfunctional in
schizophrenia and should be considered in the context of clinical trials.
Cognitive impairments in these domains are also seen in bipolar disorder, but
they tend to be milder. These impairments seem to be a core feature of
schizophrenia and exist outside of mood episodes in bipolar disorder.
Impairments are present in unaffected relatives of patients with schizophrenia
or bipolar disorder, can serve as an endophenotype for both illnesses, and are
linked to community functioning.
(J Clin Psychiatry
From the Department of
Psychiatry and Biobehavioral Sciences, University of California, Los Angeles,
and the VA Greater Los Angeles Healthcare System, Los Angeles