The Journal of
Clinical Psychiatry
The Official Journal of the American Society of Clinical Psychopharmacology
Peer-Reviewed, Evidence-Based Scientific Information
Efficacy and Effectiveness of Depot Versus Oral Antipsychotics in Schizophrenia: Synthesizing Results Across Different Research Designs
Noam Y. Kirson, Peter J. Weiden, Sander Yermakov, Wayne Huang, Thomas Samuelson, Steve J. Offord, Paul E. Greenberg, and Bruce J. O. Wong
Long-acting (depot) antipsychotic medications are often recommended to address adherence problems in patients with schizophrenia, but evidence on the comparative effectiveness of depot versus oral antipsychotics is inconsistent. The authors of this article hypothesized that this inconsistency is due to systematic differences in study design. They conducted a targeted literature review and meta-analysis to test this hypothesis.
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