Primary Care Companion E-lert

01.28.13

The Primary Care Companion for
CNS Disorders

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Improvement in Functional Outcomes With Adjunctive Aripiprazole Versus Placebo in Major Depressive Disorder: A Pooled Post Hoc Analysis of 3 Short-Term Studies

Tanya J. Fabian, PharmD, PhD; Zachary J. Cain, PharmD; Diane Ammerman, PharmD; James M. Eudicone, MS, MBA; Yan Tang, MS; Linda M. Rollin, PhD; Robert A. Forbes, PhD; Robert M. Berman, MD; and Ross A. Baker, PhD, MBA

A potential treatment option for residual depressive symptoms is to add a low-dose antipsychotic to an antidepressant regimen. In this article, Fabian and colleagues analyzed data from 3 similarly designed clinical trials that investigated the effect of combining the atypical antipsychotic aripiprazole with an antidepressant on improving a patient’s functional impairment compared with receiving antidepressants alone.

[Abstract] [Full Text]

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