Primary Care Companion E-lert

10.24.12

The Primary Care Companion for
CNS Disorders

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Aripiprazole Partial Agonism at 5-HT2C: A Comparison of Weight Gain Associated With Aripiprazole Adjunctive to Antidepressants With High Versus Low Serotonergic Activities

Charles T. Nguyen, MD; Jennifer A. Rosen, PharmD, BCPP; and Robert G. Bota, MD, MSG

Aripiprazole is a partial agonist at several receptor sites, including 5-HT2C, which has been associated with increased food intake. The authors of this study theorize that aripiprazole may have varying effects on weight depending on whether it exhibits more of an antagonist or agonist effect at the 5-HT2C receptor. They hypothesize that in the presence of antidepressants with high serotonergic activity, aripiprazole may increase the potential for weight gain. Conversely, in environments with low serotonergic activity, aripiprazole may have less of an effect on weight.

[Abstract] [Full Text]

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