Primary Care Companion E-lert


The Primary Care Companion for
CNS Disorders

Register | Current Issue | Information for Authors | About E-Lerts | CNS for Primary Care Publisher's Podcast

Aripiprazole Partial Agonism at 5-HT2C: A Comparison of Weight Gain Associated With Aripiprazole Adjunctive to Antidepressants With High Versus Low Serotonergic Activities

Charles T. Nguyen, MD; Jennifer A. Rosen, PharmD, BCPP; and Robert G. Bota, MD, MSG

Aripiprazole is a partial agonist at several receptor sites, including 5-HT2C, which has been associated with increased food intake. The authors of this study theorize that aripiprazole may have varying effects on weight depending on whether it exhibits more of an antagonist or agonist effect at the 5-HT2C receptor. They hypothesize that in the presence of antidepressants with high serotonergic activity, aripiprazole may increase the potential for weight gain. Conversely, in environments with low serotonergic activity, aripiprazole may have less of an effect on weight.

[Abstract] [Full Text]

For more free peer-reviewed articles, visit the Companion at If you are having trouble reading this E-Lert, see

Like us on Facebook
Follow us on Twitter

You are receiving this update as a benefit of your membership.

To ensure delivery of these messages add to your address book. If you would not like to receive further E-Lerts, go to and click the "Unsubscribe from E-Lerts" link. If you are having trouble unsubscribing, contact the web administrator for assistance.

If you are having trouble with your membership, contact our circulation department. Direct any other questions or comments to the web administrator.

Physicians Postgraduate Press, Inc. | 850 Ridge Lake Boulevard, Suite 300 | Memphis, TN 38120

Please do not reply directly to this e-mail. Neither nor any of its family of websites will ask you to send us profile information via e-mail.

If you cannot read this, go to

© Copyright 2012, Physicians Postgraduate Press, Inc. All rights reserved.