Primary Care Companion E-lert

11.14.12

The Primary Care Companion for
CNS Disorders

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Beneficial Effects of the Sigma-1 Agonist Fluvoxamine for Tardive Dyskinesia in Patients With Postpsychotic Depressive Disorder of Schizophrenia: Report of 5 Cases

Yakup Albayrak, MD, and Kenji Hashimoto, PhD

Tardive dyskinesia is characterized by involuntary, repetitive, purposeless movements that can affect different parts of the body. It is a well-known side effect of conventional antipsychotics. Fluvoxamine may be an effective treatment for neuropsychiatric disorders via sigma-1 receptor agonism. Here, Albayrak and colleagues report 5 cases in which fluvoxamine was beneficial for both postpsychotic depressive disorder and tardive dyskinesia in patients with schizophrenia.

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