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Beneficial Effects of Adjunctive Aripiprazole in Major Depressive Disorder Are Not Dependent on Antidepressant Therapy History: A Post Hoc Analysis of 3 Randomized, Double-Blind, Placebo-Controlled Trials

David L. Dunner, MD, FACPsych; Kimberly K. Laubmeier, PhD; George Manos,PhD; Robert A. Forbes, PhD; Ross A. Baker, PhD; and Robert M. Berman, MD

Aripiprazole is an atypical antipsychotic that is a proven augmentation option for patients with an inadequate response to antidepressant therapy. However, it is unclear how previous antidepressant treatment may affect future response to aripiprazole. Review results from a study that examined whether switching within or between antidepressant therapy classes prior to the use of adjunctive aripiprazole is associated with different outcomes in major depressive disorder.

[Abstract] [Full Text]

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