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Focus on Alzheimer’s Disease and Related Disorders

Eric M. Reiman, M.D., serves as deputy editor of this section, which encourages scientific studies of Alzheimer’s disease, promotes the optimal care of patients, and helps to keep the psychiatric community informed of the latest scientific and clinical developments. See our information on submitting a manuscript to this section.

2012 December

Gender Differences in Clinical Manifestations and Outcomes Among Hospitalized Patients With Behavioral and Psychological Symptoms of Dementia

Tatsuru Kitamura, Maki Kitamura, Shoryoku Hino, Nana Tanaka, and Koichi Kurata

[Abstract] [Full Text]

Association Between White Matter Hyperintensity Severity and Cognitive Impairment According to the Presence of the Apolipoprotein E (APOE) e4 Allele in the Elderly: Retrospective Analysis of Data From the CREDOS Study

Sang Joon Son, Kang Soo Lee, Yunhwan Lee, Jong Hwan Baek, Seong Hye Choi, Duk L. Na, Sang Won Seo, Byoung Hoon Oh, and Chang Hyung Hong

[Abstract] [Full Text]

Long-Term Observation of a Multicomponent Cognitive Intervention in Mild Cognitive Impairment

Verena C. Buschert, Ina Giegling, Stefan J. Teipel, Sabrina Jolk, Harald Hampel, Dan Rujescu, and Katharina Buerger

[Abstract] [Full Text]

2012 September

A Meta-Analytic Review of Polyunsaturated Fatty Acid Compositions in Dementia

Pao-Yen Lin, Chih-Chiang Chiu, Shih-Yi Huang, and Kuan-Pin Su

[Abstract] [Full Text]

Efficacy of Nonpharmacologic Interventions for Agitation in Advanced Dementia: A Randomized, Placebo-Controlled Trial

Jiska Cohen-Mansfield, Khin Thein, Marcia S. Marx, Maha Dakheel-Ali, and Laurence Freedman

[Abstract] [Full Text]

2012 March

The Relationships of Environment and Personal Characteristics to Agitated Behaviors in Nursing Home Residents With Dementia

Jiska Cohen-Mansfield, Khin Thein, Marcia S. Marx, Maha Dakheel-Ali, Havi Murad, and Laurence S. Freedman

[Abstract] [Full Text]

2012 January

Metabolism of Amyloid-ß Protein May Be Affected in Depression

Hajime Baba, Yoshiyuki Nakano, Hitoshi Maeshima, Emi Satomura, Yohei Kita, Toshihito Suzuki, and Heii Arai

[Abstract] [Full Text]

Effect of Second-Generation Antipsychotics on Caregiver Burden in Alzheimer’s Disease

Somaia Mohamed, Robert Rosenheck, Constantine G. Lyketsos, Richard Kaczynski, PhD; David L. Sultzer, and Lon S. Schneider

[Abstract] [Full Text]

2011 April

Prediction of Alzheimer’s Disease Using Midregional Proadrenomedullin and Midregional Proatrial Natriuretic Peptide: A Retrospective Analysis of 134 Patients With Mild Cognitive Impairment

Katharina Buerger, Olga Uspenskaya, Oliver Hartmann, Oskar Hansson, Lennart Minthon, Kaj Blennow, Hans-Juergen Moeller, Stefan J. Teipel, Andrea Ernst, Andreas Bergmann, and Harald Hampel

[Abstract] [Full Text]

2010 October

Persistent Depressive Symptoms and Cognitive Function in Late Midlife: The Whitehall II Study.

Archana Singh-Manoux, Tasnime N. Akbaraly, Michael Marmot, Maria Melchior, Joël Ankri, Séverine Sabia, and Jane E. Ferrie

[Abstract] [Full Text]

Abnormal Integrity of Long Association Fiber Tracts Is Associated With Cognitive Deficits in Patients With Remitted Geriatric Depression: A Cross-Sectional, Case-Control Study.

Yonggui Yuan, Zhenghua Hou, Zhijun Zhang, Feng Bai, Hui Yu, Jiayong You, Yongmei Shi, Wen Liu, and Tianzi Jiang

[Abstract] [Full Text]

2010 January

Cognizance of Cognition in Older Primary Care Patients With Depression and Restraining Restraint and Agitation in Nursing Home Residents With Dementia.

Eric M. Reiman

[Full Text]

Depression Predicts Cognitive Disorders in Older Primary Care Patients.

Lisa L. Boyle, Anton P. Porsteinsson, Xingjia Cui, Deborah A. King, and Jeffrey M. Lyness

[Abstract/Purchase] [Full Text]

The Effect of Staff Training on Agitation and Use of Restraint in Nursing Home Residents With Dementia: A Single-Blind, Randomized Controlled Trial.

Ingelin Testad, Clive Ballard, Kolbjørn Brønnick, and Dag Aarsland

[Abstract/Purchase] [Full Text]

2009 June

Introduction. Untangling the Roles of Antidepressants and Mood Stabilizers in the Treatment of Alzheimer's Disease.

Eric M. Reiman

[PDF]

Effect of a Serotonin Reuptake Inhibitor on Irritability, Apathy, and Psychotic Symptoms in Patients With Alzheimer's Disease.

Haroon Siddique, Linda S. Hynan, and Myron F. Weiner

[Abstract] [PDF]

Commentary. Can Lithium or Valproate Untie Tangles in Alzheimer's Disease?

Pierre N. Tariot and Paul S. Aisen

[PDF]

Lithium Trial in Alzheimer's Disease: A Randomized, Single-Blind, Placebo-Controlled, Multicenter 10-Week Study.

Harald Hampel, Michael Ewers, Katharina Bürger, Peter Annas, Anette Mörtberg, Anna Bogstedt, Lutz Frölich, Johannes Schröder, Peter Schönknecht, Matthias W. Riepe, Inga Kraft, Thomas Gasser, Thomas Leyhe, Hans-Jürgen Möller, Alexander Kurz, and Hans Basun

[Abstract] [PDF]

2009 April

Commentary. Grumpy Old Men (and Women): Mere Hassle or Meaningful Clinical Evidence?

Anton P. Porsteinsson and Kelly M. Cosman

[PDF]

Mild Behavioral Impairment and Risk of Dementia: A Prospective Cohort Study of 358 Patients

Fernando E. Taragano, Ricardo F. Allegri, Hugo Krupitzki, Diego R. Sarasola, Cecilia M. Serrano, Leandro Loñ, and Constantine G. Lyketsos

[Abstract] [PDF]

2007 April

Entering the Era of High-Density Genome-Wide Association Studies

Eric M. Reiman

[PDF]

A High-Density Whole-Genome Association Study Reveals That APOE Is the Major Susceptibility Gene for Sporadic Late-Onset Alzheimer's Disease

Keith D. Coon, Amanda J. Myers, David W. Craig, Jennifer A. Webster, John V. Pearson, Diane Hu Lince, Victoria L. Zismann, Thomas G. Beach, Doris Leung, Leslie Bryden, Rebecca F. Halperin, Lauren Marlowe, Mona Kaleem, Douglas G. Walker, Rivka Ravid, Christopher B. Heward, Joseph Rogers, Andreas Papassotiropoulos, Eric M. Reiman, John Hardy, and Dietrich A. Stephan

[Abstract] [PDF]

2007 March

Clinical Trials and Tribulations

Eric M. Reiman

[PDF]

Study Design Factors and Patient Demographics and Their Effect on the Decline of Placebo-Treated Subjects in Randomized Clinical Trials in Alzheimer's Disease

Michael Gold

[Abstract] [PDF]

Antiaggressive Effect of Cyproterone Versus Haloperidol in Alzheimer's Disease: A Randomized Double-Blind Pilot Study

David Huertas, Juan J. López-Ibor Aliño, Juan D. Molina, Lorenzo Chamorro, Juana Balanza, María P. Jiménez, and Mercedes Hornillos

[Abstract] [PDF]

Helping Families With End-of-Life Care in Alzheimer's Disease

Paul Kettl

[Abstract] [PDF]

2006 December

The Non-Alzheimer Dementias

Eric M. Reiman

[PDF]

A Review of the Non-Alzheimer Dementias

Bradley F. Boeve

[Abstract] [PDF]

2006 November

A 100-Year Update on Alzheimer's Disease and Related Disorders

Eric M. Reiman

[PDF]

Alzheimer's Disease A Century Later

Richard J. Caselli, Thomas G. Beach, Roy Yaari, and Eric M. Reiman

[Abstract] [PDF]

2006 April

The Genetic, Transcriptomic, and Proteomic Study of Alzheimer's Disease

Eric M. Reiman

[PDF]

Genetics, Transcriptomics, and Proteomics of Alzheimer's Disease

Andreas Papassotiropoulos, Michael Fountoulakis, Travis Dunckley, Dietrich A. Stephan, and Eric M. Reiman

[Abstract] [PDF]

2005 July

Genetics, Cholesterol, and the Risk of Alzheimer's Disease

Eric M. Reiman

[PDF]

A Cluster of Cholesterol-Related Genes Confers Susceptibility for Alzheimer's Disease

Andreas Papassotiropoulos, M. Axel Wollmer, Magdalini Tsolaki, Fabienne Brunner, Dimitra Molyva, Dieter Lütjohann, Roger M. Nitsch, and Christoph Hock

[Abstract] [PDF]