Anticipated Reward in Obsessive-Compulsive Disorder: Are Compulsions Rewarding?

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Anticipated Reward in Obsessive-Compulsive Disorder: Are Compulsions Rewarding?

To the Editor: Affect and behavior are closely linked. Researchers have investigated the influence of affective reactions to incentive outcomes on behavior. More recently, interest has shifted to the affective state that occurs during the anticipation of a behavior. Affect during this phase is best situated in time to motivate behavior and is typically associated with the expected outcomes of that behavior.1 This notion is relevant for compulsive behavior in obsessive-compulsive disorder (OCD), which is associated with a deficit in using accurate models of prospective action-outcome scenarios.2 This deficit may in turn influence anticipatory affect and exacerbate compulsions despite their detrimental consequences. More insight into the affective changes before and after compulsions in OCD can increase our understanding of how affect and behavior dynamically interact in this disorder. In this study, we directly investigated self-reported affect before, in anticipation of, and after OCD-related compulsions to elucidate the role of positive and negative affective states in compulsive behavior.

Method. Twenty-two consecutive and treatment-seeking patients with DSM-IV OCD (mean ± SD age = 39.17 ± 12.42 years, 11 males) completed the Temporal Impulsive Compulsive Scale, a self-report instrument that was developed to assess affective states over time during specific repetitive behaviors (scale is available from the authors upon request). It consists of a selection of 6 Positive Affect (cheerful, proud, determined, confident, energetic, alert) and 8 Negative Affect (guilty, lonely, nervous, sad, afraid, disgust, ashamed, irritable) items from the Positive and Negative Affective Schedule (PANAS). Participants indicated how intensely they experienced these affective states before (pre-choice phase), in anticipation of (anticipatory phase), and after (consummatory phase) their primary OCD compulsion behavior (ie, washing, checking, ordering, or hoarding). This study was approved by the local institutional review board.

Scores were calculated (in centimeters) using a visual analog scale that varied from 0 "not at all" to 10 "extremely." Mean responses were separately calculated for positive and negative affect at each temporal phase. Each participant received 1 mean score for items within the Positive Affect scale and 1 for items within the Negative Affect scale. We defined increase or decrease in positive or negative affect when patients showed a difference of more than 1 standard deviation shift from the pre-choice phase to the anticipatory phase.

Results. Twenty of the 22 OCD patients showed an increase in mean positive affect from pre-choice to anticipatory phase, while 2 patients showed no change in affect. Of the 20 patients, 10 additionally reported a decrease in mean negative affect (Figure 1). At the item level, when the pre-choice phase was compared to the anticipatory phase, there was increased positive affect in relation to being determined (n = 9), energetic (n = 7), confident (n = 6), cheerful (n = 5), and alert (n = 4), as well as decreased negative affect in relation to being sad (n = 6), irritable (n = 4), ashamed (n = 3), guilty (n = 2), nervous (n = 2), afraid (n = 2), disgusted (n = 1), and lonely (n = 1).

Click figure to enlarge

The 10 patients who showed a decrease in negative affect included 3 with washing compulsions, 3 with checking compulsions, 3 with hoarding compulsions, and 1 with symmetry symptoms. The remaining 10 patients showed either a concomitant increase (n = 6) or no change (n = 4) in negative affect during the shift from pre-choice to the anticipatory phase. These patients included 3 with washing compulsions, 3 with checking compulsions, 2 with hoarding compulsions, and 2 with symmetry symptoms. Mixed compulsive and impulsive OCD patients (ie, patients who exhibited both increases in mean positive and decreases in mean negative affect) exhibited more frequent decreases in sadness (P = .01; Fisher exact test) and a trend toward more frequent decreases in irritability (P = .08; Fisher test) than purely impulsive patients (patients who displayed only an increase in mean positive affect). Age (Z = −0.2; P = .85) and gender (P = 1.00; Fisher test) did not differ between mixed OCD patients with impulsive and compulsive features versus purely impulsive patients.

Discussion. It is intriguing that almost all of the OCD patients studied showed an increase in positive affect in anticipation of their compulsion. In addition, 10 of them showed a concurrent decrease in negative affect, while the remainder showed either a concurrent increase or no change in negative affect. The increase in positive anticipatory affect may indicate a rewarding aspect of compulsions, and concomitant decreases in negative affect (particularly sadness and irritability) suggest craving/addictive processes, which could contribute to the persistence of these behaviors. These findings may be particularly relevant to those OCD patients who show blunted nucleus accumbens activity during anticipation of generic rewards, which is offset by enhanced activity during anticipation of performing OCD-related compulsions. This explanation supports analogies between OCD and addiction3 and is consistent with the co-occurrence of compulsive and impulsive symptoms in OCD4 and addictive disorders.5 The findings provide insights into the phenomenological and neurobiological systems that maintain, and even promote, compulsions in OCD-related behaviors.

References

1. Knutson B, Greer SM. Anticipatory affect: neural correlates and consequences for choice. Philos Trans R Soc Lond B Biol Sci. 2008;363(1511):3771-3786. PubMed doi:10.1098/rstb.2008.0155

2. Gillan CM, Morein-Zamir S, Kaser M, et al. Counterfactual processing of economic action-outcome alternatives in obsessive-compulsive disorder: further evidence of impaired goal-directed behavior. Biol Psychiatry. 2014;75(8):639-646. PubMed doi:10.1016/j.biopsych.2013.01.018

3. Figee M, Vink M, de Geus F, et al. Dysfunctional reward circuitry in obsessive-compulsive disorder. Biol Psychiatry. 2011;69(9):867-874. PubMed doi:10.1016/j.biopsych.2010.12.003

4. Kashyap H, Fontenelle LF, Miguel EC, et al. "Impulsive compulsivity" in obsessive-compulsive disorder: a phenotypic marker of patients with poor clinical outcome. J Psychiatr Res. 2012;46(9):1146-1152. PubMed doi:10.1016/j.jpsychires.2012.04.022

5. Leeman RF, Potenza MN. Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity. Psychopharmacology (Berl). 2012;219(2):469-490. PubMed doi:10.1007/s00213-011-2550-7

Leonardo F. Fontenelle, MD, PhD

Sanne Oostermeijer, MA

Gabriela Mourão Ferreira, MD

Valentina Lorenzetti, PhD

Judy Luigjes, MA

Murat Yücel, PhD

murat.yucel@monash.edu

Author affiliations: Anxiety and Obsessive-Compulsive Spectrum Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ) (Drs Fontenelle and Ferreira) and D’ Or Institute for Research and Education (IDOR) (Dr Fontenelle), Rio de Janeiro, Brazil; Monash Clinical and Imaging Neuroscience (MCIN) Laboratory, School of Psychological Sciences & Monash Biomedical Imaging (MBI) Facility, Monash University, Victoria, Australia (Drs Fontenelle, Lorenzetti, and Yücel); Department of Child and Adolescent Psychiatry, VU University Medical Centre Amsterdam (CAPVUMCA) (Ms Oostermeijer); and Department of Psychiatry, Academic Medical Center, University of Amsterdam (Ms Luigjes), The Netherlands.

Potential conflicts of interest: None reported.

Funding/support: This work was supported by grants from D’ Or Institute for Research and Education (IDOR), National Council for Scientific and Technological Development (CNPQ), and Rio de Janeiro State Foundation for Research Support (FAPERJ).

J Clin Psychiatry 2015;76(9):e1134-e1135

dx.doi.org/10.4088/JCP.14l09499

© Copyright 2015 Physicians Postgraduate Press, Inc.