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In Bipolar Disorder Beyond 10 Weeks of Treatment, the Term <em>Antidepressants</em> Is a Misnomer

J Clin Psychiatry 2011;72(6):871 [letter]

Letter to the Editor

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In a January 2011 letter to the editor commenting on the article by Ghaemi et al, Dr Keith Rasmussen describes the finding of more depression in bipolar patients treated with antidepressants as if both new and surprising. In my opinion, it is neither. Two other recent studies have looked at rates of depression in bipolar disorder patients treated with and without antidepressants and found that those treated with antidepressants had twice as many depressed days, significantly higher CGI-BP depression scores (P < .001), and a significantly higher rate of depressive relapse (P < .001) at 12 weeks and 24 months.