Childhood Trauma and Depressive Symptoms in Type 1 Diabetes
J Clin Psychiatry 2011;72(8):1049-1053
© Copyright 2015 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: To examine the relationship of childhood trauma to depressive symptoms in type 1 diabetes, a chronic disease in which the frequency of depression is increased.
Method: One hundred fifty African American patients with type 1 diabetes seen between August 1993 and January 1998 completed the Beck Depression Inventory and Childhood Trauma Questionnaire. They were also genotyped for a functional serotonin transporter promoter polymorphism (5-HTTLPR) that modulates resiliency. Patients who had Beck Depression Inventory scores above and below 14 were compared.
Results: Diabetic patients who had Beck Depression Inventory scores ≥ 14 had experienced significantly more different types of childhood trauma than those with Beck Depression Inventory scores < 14 (P < .001), independent of potential interaction with 5-HTTLPR genotype.
Conclusions: Childhood trauma appears to be a determinant of depressive symptoms in type 1 diabetes, independently of genotype of a functional locus modulating resiliency.
J Clin Psychiatry 2011;72(8):1049–1053
Submitted: November 25, 2009; accepted January 27, 2010.
Online ahead of print: October 19, 2010 (doi:10.4088/JCP.09m05857blu).
Corresponding author: Alec Roy, MD, Psychiatry Service (116A), Department of Veterans Affairs, NJHCS, 385 Tremont Ave, East Orange, NJ 07018 (Alec.Roy@va.gov).