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Commentary: Randomized Controlled Trials of Olanzapine Treatment of Borderline Personality Disorder: Two Similar Studies With Different Results

J Clin Psychiatry 2011;72(10):1363-1365
10.4088/JCP.11com06844

The author presents a comparison of 2 large concurrently conducted, industry-sponsored, randomized, placebo-controlled pharmacotherapy trials using essentially the same protocols and outcome measures and differing primarily on fixed-dose versus flexible-dose olanzapine administration for treatment. Since the published reports of these 2 trials are 2+ years apart, with 1 included in the same issue as this commentary, it is important to bring together the results of these trials.