The article you requested is

Can Pindolol Really Enhance Antidepressant Effect?

J Clin Psychiatry 2011;72(11):1558 [letter]

Letter to the Editor

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To the Editor: In their recent article, Portella and colleagues1 claim that pindolol can accelerate and enhance antidepressant effect of selective serotonin reuptake inhibitors (SSRIs). As one of the authors of another recent meta-analysis of pindolol augmentation,2 I would like to comment on their results.

From their meta-analysis,1 the number needed to treat (NNT) was calculated as 6 for early clinical response (ie, acceleration of antidepressant effect at 10 days to 2 weeks) and as 13 for late clinical response (ie, enhancement of antidepressant effect at 4 to 6 weeks).