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Commentary: Can We Incorporate Psychosocial Treatment Interventions Into Psychopharmacology Clinical Trials?

J Clin Psychiatry 2012;73(7):1023-1024
10.4088/JCP.12com07829

Dr. Schooler believes that the article by Richard Keefe and colleagues in this month’s Journal has substantial value to researchers who face an important methodological question in clinical trials of cognitive-enhancing medications in schizophrenia. Do patients in pharmacologic intervention trials need to exercise their cognitive “muscles” for a drug that increases cognitive “muscle mass” to work? This analogy is offered by Keefe et al in their feasibility study of adding cognitive remediation to pharmacologic trials. Dr. Schooler provides an engaging discussion of their study and of the topic in general.