VOLUME 65   2004   SUPPLEMENT 4

ARTICLES

3 Introduction. Pharmacologic Treatments of Major Depression:Are Two Mechanisms Really Better Than One? Alan F. Schatzberg
[PDF]

5 Selectivity of Antidepressants: From the Monoamine Hypothesis of Depression to the SSRI Revolution and Beyond. Michael J. Owens
[Abstract] [PDF]

11 Distinguishing Roles for Norepinephrine and Serotonin in the Behavioral Effects of Antidepressant Drugs. Irwin Lucki and Olivia F. O'Leary
[Abstract] [PDF]

25 How Antidepressants Help Depression:Mechanisms of Action and Clinical Response. Pedro L. Delgado
[Abstract] [PDF]

31 Are Two Antidepressant Mechanisms Better Than One? Issues in Clinical Trial Design and Analysis. Andrew C. Leon
[Abstract] [PDF]

37 Selective Versus Multi-Transmitter Antidepressants: Are Two Mechanisms Better Than One? William J. Burke
[Abstract] [PDF]

46 Newer Antidepressants: Review of Efficacy and Safety of Escitalopram and Duloxetine. Robert M. A. Hirschfeld and Lana A. Vornik
[Abstract] [PDF]

53 Remission Versus Response: The New Gold Standard of Antidepressant Care. Martin B. Keller
[Abstract] [PDF]

60 Debate and Discussion: In the Treatment of Depression, Does Selectivity of Action Matter?
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