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VOLUME 69   2008   NUMBER 10

Original Articles

1513 The History and Current State of Antidepressant Clinical Trial Design: A Call to Action for Proof-of-Concept Studies. Alan J. Gelenberg, Michael E. Thase, Roger E. Meyer, Frederick K. Goodwin, Martin M. Katz, Helena Chmura Kraemer, William Z. Potter, Richard C. Shelton, Maurizio Fava, Arif Khan, Madhukar H. Trivedi, Philip T. Ninan, John J. Mann, Susan Bergeson, Jean Endicott, James H. Kocsis, Andrew C. Leon, Husseini K. Manji, and Jerrold F. Rosenbaum
[Abstract] [PDF]

1529 A Pooled Analysis of Gender and Trauma-Type Effects on Responsiveness to Treatment of PTSD With Venlafaxine Extended Release or Placebo. Barbara O. Rothbaum, Jonathan R. T. Davidson, Dan J. Stein, Ron Pedersen, Jeff Musgnung, Xiao Wei Tian, Saeeduddin Ahmed, and David S. Baldwin
[Abstract] [PDF]

1540 Patterns of Atypical Antipsychotic Subtherapeutic Dosing Among Oregon Medicaid Patients. Daniel M. Hartung, Jennifer P. Wisdom, David A. Pollack, Ann M. Hamer, Dean G. Haxby, Luke Middleton, and Bentson H. McFarland
[Abstract] [PDF]

1548 A Cross-Sectional Study of Patients' Perspectives on Adherence to Antipsychotic Medication: Depot Versus Oral. Maxine X. Patel, Nicole de Zoysa, Morris Bernadt, and Anthony S. David
[Abstract] [PDF]

1557 Efficacy and Safety of Doxepin 1 mg, 3 mg, and 6 mg in Elderly Patients With Primary Insomnia: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. Martin Scharf, Roberta Rogowski, Steven Hull, Martin Cohn, David Mayleben, Neil Feldman, Larry Ereshefsky, Alan Lankford, and Thomas Roth
[Abstract] [PDF]

1565 Serotonin-System Polymorphisms (5-HTTLPR and -1438G/A) and Responses of Patients With Bulimic Syndromes to Multimodal Treatments. Howard Steiger, Ridha Joober, Lise Gauvin, Kenneth R. Bruce, Jodie Richardson, Mimi Israel, Annelie S. Anestin, and Patricia Groleau
[Abstract] [PDF]

1572 Is Flunarizine a Long-Acting Oral Atypical Antipsychotic? A Randomized Clinical Trial Versus Haloperidol for the Treatment of Schizophrenia. Luísa W. Bisol, Miriam G. Brunstein, Gustavo L. Ottoni, Fernanda L. P. Ramos, Daniela L. Borba, Claudiane S. Daltio, Ricardo V. de Oliveira, Gisele E. G. Paz, Sayuri E. de Souza, Rodrigo A. Bressan, and Diogo R. Lara
[Abstract] [PDF]

1580 Tardive Dyskinesia and the 3-Year Course of Schizophrenia: Results From a Large, Prospective, Naturalistic Study. Haya Ascher-Svanum, Baojin Zhu, Douglas Faries, Xiaomei Peng, Bruce J. Kinon, and Mauricio Tohen
[Abstract] [PDF]

1589 Antidepressant-Associated Mood Elevations in Bipolar II Disorder Compared With Bipolar I Disorder and Major Depressive Disorder: A Systematic Review and Meta-Analysis. David J. Bond, Melissa M. Noronha, Marcia Kauer-Sant'Anna, Raymond W. Lam, and Lakshmi N. Yatham
[Abstract] [PDF]

Focus on Women's Mental Health

1602 Perinatal Disorders: Advancing Public Health Opportunities. Katherine L. Wisner, Sarah Hudson Scholle, and Bradley Stein
[PDF]

1606 Gender Differences in Generalized Anxiety Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Oriana Vesga-López, Franklin R. Schneier, Samuel Wang, Richard G. Heimberg, Shang-Min Liu, Deborah S. Hasin, and Carlos Blanco
[Abstract] [PDF]

1617 Axis I Psychopathology and Functional Impairment at the Third Month of Pregnancy: Results From the Perinatal Depression-Research and Screening Unit (PND-ReScU) Study. Chiara Borri, Mauro Mauri, Annalisa Oppo, Susanna Banti, Cristina Rambelli, Daniele Ramacciotti, Maria S. Montagnani, Valeria Camilleri, Sonia Cortopassi, Amparo Bettini, Serena Ricciardulli, Paola Rucci, Simone Montaresi, and Giovanni B. Cassano
[Abstract] [PDF]

1625 A Closer Look at Depression in Mothers Who Kill Their Children: Is It Unipolar or Bipolar Depression? Jeong-Hyun Kim, Sang Sub Choi, and Kyooseob Ha
[Abstract] [PDF]

Academic Highlights

1632 International Consensus Group on the Evidence-Based Pharmacologic Treatment of Bipolar I and II Depression. [CME]
[PDF]

1647 Obsessive-Compulsive Disorder: Strategies for Optimal Treatment. [CME]
[PDF]

ASCP Corner [PDF]

1658 The Search for Knowledge: Developing the American Psychiatric Association's Practice Guideline for Major Depressive Disorder. Alan J. Gelenberg

Letters To the Editor

1660 High-Dose Olanzapine Versus Clozapine. Jeffrey A. Mattes
[PDF]

  • Reply by Herbert Y. Meltzer and Karu Jayathilake
    [PDF]

1661 Depression in Physicians: Hyperfunctioning Depression or Professional Depression? Nagy A. Youssef
[PDF]

  • Reply by Thomas L. Schwenk and Loretta M. Leja
    [PDF]

1662 ECT Not Proven for Atypical Depression. Conrad M. Swartz
[PDF]

  • Reply by Shawn M. McClintock, Mustafa M. Husain, A. John Rush, Cynthia Claassen, Melanie M. Biggs, Rebecca G. Knapp, Martina Mueller, Max Fink, Samuel H. Bailine, Teresa A. Rummans, Shirlene Sampson, Georgios Petrides, Charles H. Kellner, and Sarah H. Lisanby
    [PDF]

Book Reviews 1664 [PDF]

Electronic CME Activities

Available through www.psychiatrist.com/toc

e28 Evaluating and Diagnosing Fibromyalgia and Comorbid Psychiatric Disorders. Lesley M. Arnold, Laurence A. Bradley, Daniel J. Clauw, Jennifer M. Glass, and Don L. Goldenberg
[Abstract]

e29 Effective Agents in Treating Bipolar Depression. Andrew A. Nierenberg
[Abstract]

e30 Practical Strategies for Diagnosing and Treating Depression in Women: Menopausal Transition. Claudio N. Soares
[Abstract]