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VOLUME 69 2008 NUMBER 10Original Articles 1513 The History and Current State of Antidepressant Clinical Trial Design: A Call to Action for Proof-of-Concept Studies. Alan J. Gelenberg, Michael E. Thase, Roger E. Meyer, Frederick K. Goodwin, Martin M. Katz, Helena Chmura Kraemer, William Z. Potter, Richard C. Shelton, Maurizio Fava, Arif Khan, Madhukar H. Trivedi, Philip T. Ninan, John J. Mann, Susan Bergeson, Jean Endicott, James H. Kocsis, Andrew C. Leon, Husseini K. Manji, and Jerrold F. Rosenbaum 1529 A Pooled Analysis of Gender and Trauma-Type Effects on Responsiveness to Treatment of PTSD With Venlafaxine Extended Release or Placebo. Barbara O. Rothbaum, Jonathan R. T. Davidson, Dan J. Stein, Ron Pedersen, Jeff Musgnung, Xiao Wei Tian, Saeeduddin Ahmed, and David S. Baldwin 1540 Patterns of Atypical Antipsychotic Subtherapeutic Dosing Among Oregon Medicaid Patients. Daniel M. Hartung, Jennifer P. Wisdom, David A. Pollack, Ann M. Hamer, Dean G. Haxby, Luke Middleton, and Bentson H. McFarland 1548 A Cross-Sectional Study of Patients' Perspectives on Adherence to Antipsychotic Medication: Depot Versus Oral. Maxine X. Patel, Nicole de Zoysa, Morris Bernadt, and Anthony S. David 1557 Efficacy and Safety of Doxepin 1 mg, 3 mg, and 6 mg in Elderly Patients With Primary Insomnia: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. Martin Scharf, Roberta Rogowski, Steven Hull, Martin Cohn, David Mayleben, Neil Feldman, Larry Ereshefsky, Alan Lankford, and Thomas Roth 1565 Serotonin-System Polymorphisms (5-HTTLPR and -1438G/A) and Responses of Patients With Bulimic Syndromes to Multimodal Treatments. Howard Steiger, Ridha Joober, Lise Gauvin, Kenneth R. Bruce, Jodie Richardson, Mimi Israel, Annelie S. Anestin, and Patricia Groleau 1572 Is Flunarizine a Long-Acting Oral Atypical Antipsychotic? A Randomized Clinical Trial Versus Haloperidol for the Treatment of Schizophrenia. Luísa W. Bisol, Miriam G. Brunstein, Gustavo L. Ottoni, Fernanda L. P. Ramos, Daniela L. Borba, Claudiane S. Daltio, Ricardo V. de Oliveira, Gisele E. G. Paz, Sayuri E. de Souza, Rodrigo A. Bressan, and Diogo R. Lara 1580 Tardive Dyskinesia and the 3-Year Course of Schizophrenia: Results From a Large, Prospective, Naturalistic Study. Haya Ascher-Svanum, Baojin Zhu, Douglas Faries, Xiaomei Peng, Bruce J. Kinon, and Mauricio Tohen 1589 Antidepressant-Associated Mood Elevations in Bipolar II Disorder Compared With Bipolar I Disorder and Major Depressive Disorder: A Systematic Review and Meta-Analysis. David J. Bond, Melissa M. Noronha, Marcia Kauer-Sant'Anna, Raymond W. Lam, and Lakshmi N. Yatham Focus on Women's Mental Health 1602 Perinatal Disorders: Advancing Public Health Opportunities. Katherine L. Wisner, Sarah Hudson Scholle, and Bradley Stein 1606 Gender Differences in Generalized Anxiety Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Oriana Vesga-López, Franklin R. Schneier, Samuel Wang, Richard G. Heimberg, Shang-Min Liu, Deborah S. Hasin, and Carlos Blanco 1617 Axis I Psychopathology and Functional Impairment at the Third Month of Pregnancy: Results From the Perinatal Depression-Research and Screening Unit (PND-ReScU) Study. Chiara Borri, Mauro Mauri, Annalisa Oppo, Susanna Banti, Cristina Rambelli, Daniele Ramacciotti, Maria S. Montagnani, Valeria Camilleri, Sonia Cortopassi, Amparo Bettini, Serena Ricciardulli, Paola Rucci, Simone Montaresi, and Giovanni B. Cassano 1625 A Closer Look at Depression in Mothers Who Kill Their Children: Is It Unipolar or Bipolar Depression? Jeong-Hyun Kim, Sang Sub Choi, and Kyooseob Ha Academic Highlights 1632 International Consensus Group on the Evidence-Based Pharmacologic Treatment of Bipolar I and II Depression. [CME] 1647 Obsessive-Compulsive Disorder: Strategies for Optimal Treatment. [CME] ASCP Corner [PDF] 1658 The Search for Knowledge: Developing the American Psychiatric Association's Practice Guideline for Major Depressive Disorder. Alan J. Gelenberg Letters To the Editor 1660 High-Dose Olanzapine Versus Clozapine. Jeffrey A. Mattes
1661 Depression in Physicians: Hyperfunctioning Depression or Professional Depression? Nagy A. Youssef
1662 ECT Not Proven for Atypical Depression. Conrad M. Swartz
Book Reviews 1664 [PDF] Electronic CME Activities Available through www.psychiatrist.com/toc e28 Evaluating and Diagnosing Fibromyalgia and Comorbid Psychiatric Disorders. Lesley M. Arnold, Laurence A. Bradley, Daniel J. Clauw, Jennifer M. Glass, and Don L. Goldenberg e29 Effective Agents in Treating Bipolar Depression. Andrew A. Nierenberg e30 Practical Strategies for Diagnosing and Treating Depression in Women: Menopausal Transition. Claudio N. Soares |