The article you requested is
Primary Care Companion J Clin Psychiatry 1999;1:93
© Copyright 2014 Physicians Postgraduate Press, Inc.
Background: At low doses, risperidone acts as a 5-HT2 antagonist.
Preclinical data suggest 5-HT2 antagonists may enhance
the action of serotonin. This report examines the clinical use of
risperidone to augment selective serotonin reuptake inhibitor
(SSRI) antidepressants in patients who have not responded to
SSRI therapy. Method: In 8 patients with major depressive
disorder without psychotic features (DSM-IV) who had not responded
to an SSRI, risperidone was added to the ongoing SSRI
treatment. Hamilton Rating Scale for Depression scores were
obtained before and after the addition of risperidone. Results:
These 8 patients remitted within 1 week of the addition of risperidone.
Risperidone also appeared to have beneficial effects
on sleep disturbance and sexual dysfunction. Conclusion: Risperidone
may be a useful adjunct to SSRIs in the treatment of