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Psychiatric Briefs

Primary Care Companion J Clin Psychiatry 2001;3:34-38

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Treatment of women with antipsychotic medication during pregnancy introduces the risk of prenatal exposure of the fetus to the medication. The authors examined the effects of in utero and lactation exposure to the atypical antipsychotic olanzapine in 23 prospectively identified pregnancies (i.e., identified before the outcome of pregnancy was known) and 11 retrospectively identified pregnancies (i.e., identified after delivery or abnormal result of a diagnostic procedure). Outcomes in the prospectively identified pregnancies were within the ranges identified in historical controls: spontaneous abortion occurred in 13%; stillbirth, in 5%; and prematurity, in 5%.‚Äč