Primary Care Companion J Clin Psychiatry 2001;3(1):34-38
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Treatment of women with antipsychotic medication during
pregnancy introduces the risk of prenatal exposure of the fetus
to the medication. The authors examined the effects of in utero
and lactation exposure to the atypical antipsychotic olanzapine
in 23 prospectively identified pregnancies (i.e., identified before
the outcome of pregnancy was known) and 11 retrospectively
identified pregnancies (i.e., identified after delivery or
abnormal result of a diagnostic procedure). Outcomes in the
prospectively identified pregnancies were within the ranges
identified in historical controls: spontaneous abortion occurred
in 13%; stillbirth, in 5%; and prematurity, in 5%.