Nitric Oxide Physiology and Pharmacology
Stephen M. Stahl, M.D., Ph.D.
|During neurotransmission in
the brain, some postsynaptic elements form nitric oxide
gas (NO) in response to nerve stimulation. The enzyme
nitric oxide synthase (NOS) synthesizes NO1-4
by converting the amino acid arginine into both NO and
the by-product citrulline. This free NO is then able to
diffuse ("talk back") to the presynaptic
neuron, which could be how 2-way communication between
presynaptic and postsynaptic elements occurs in some CNS
Brainstorms aims to provide updates of novel concepts emerging from the neurosciences that have relevance to practitioners.
From the Clinical Neuroscience Research Center in San Diego and the Department of Psychiatry at the University of california San Diego.