November 24, 2020
Outcomes of Neuroleptic Malignant Syndrome With Depot Versus Oral Antipsychotics: A Systematic Review and Pooled, Patient-Level Analysis of 662 Case Reports
Is the advantage of longer-term medication release with long-acting injectable antipsychotics offset by an increased risk of more prolonged and severe neuroleptic malignant syndrome? This systematic review and pooled analysis address that question.
Long-Acting Injectable Antipsychotic Use During Pregnancy: A Brief Review and Concise Guide for Clinicians
Women with psychotic and mood disorders are at greater risk of symptoms during pregnancy, but some clinicians avoid use of LAIs in these patients due to safety concerns. This article highlights points to consider in the decision-making process.
This article examines a role for gabapentin in reducing alcohol consumption in a specific subpopulation of alcohol use disorder patients: those with high alcohol intake and high levels of withdrawal symptoms.
Sleep experts Drs Roth and Winkelman explore the differential diagnosis and treatment of narcolepsy in this CME journal activity.
November 17, 2020
In this letter to the editor, Finsterer and colleagues comment on an article by Manu et al.
Cost-Effectiveness of Routine Screening for Autoimmune Encephalitis in Patients With First-Episode Psychosis in the United States
Autoimmune encephalitis (AE) is a highly treatable neurologic condition that can cause psychosis. This study estimated the cost-effectiveness of routine screening for AE compared with clinically targeted screening in first-episode psychosis patients.
Since the association of the inflammatory biomarker hs-CRP with depression is unclear, alternative inflammatory biomarkers of depression are needed. This study examined the association between the inflammatory biomarker GlycA and depressive symptoms.
November 10, 2020
Predictors of Loneliness by Age Decade: Study of Psychological and Environmental Factors in 2,843 Community-Dwelling Americans Aged 20-69 Years
Reducing loneliness is a public health priority, but current interventions focused solely on decreasing social isolation have been only modestly effective. This study examined age-related differences in risk and protective factors for loneliness.
A Proof-of-Concept Study of Subanesthetic Intravenous Ketamine Combined With Prolonged Exposure Therapy Among Veterans With Posttraumatic Stress Disorder
Prolonged exposure is a gold-standard trauma therapy, but trials in military populations show not all patients experience symptom improvement. This 10-week pilot looked at the feasibility of combining ketamine and prolonged exposure for better outcomes.
This commentary discusses the implications of a recent article by Chen et al that investigated whether a patient's happiness level during ketamine infusion can predict their eventual antidepressant response to it.
Happiness During Low-Dose Ketamine Infusion Predicts Treatment Response: Reexploring the Adjunctive Ketamine Study of Taiwanese Patients With Treatment-Resistant Depression
Can we determine which patients will respond to ketamine just by observing their mood during the infusion? This study evaluated antidepressant outcomes with ketamine in 71 patients, focusing on their self-rated happiness, or lack of it, during infusion.
November 3, 2020
Measurement-based care (MBC) has been found to be effective in patients with psychiatric conditions. In this CME activity, learn how Dr Joseph McEvoy employs MBC for patients with tardive dyskinesia.
Differences in Prescription Stimulant Misuse Motives Across Adolescents and Young Adults in the United States
Prescription stimulant misuse (PSM) is common in adolescents and young adults. Do motives for PSM differ by age in these individuals? This study examined PSM motives across age decades using the 2015-2018 National Survey on Drug Use and Health.
When you treat patients with dementia-related psychosis, do you evaluate the burden on carers, too? If they feel discomfort, fear, or depression, how would you help them? Learn from an expert in this brief CME activity.
Collaborating With Patients to Make Treatment Decisions Based on Benefits and Risks of Medications Associated With Tardive Dyskinesia
Do you know how to talk with your patients about the risk for tardive dyskinesia? Follow along as Dr Nierenberg offers tips for clear communication.
Predictors of Bipolar Disorder Versus Schizophrenia Diagnosis in a Multicenter First Psychotic Episode Cohort: Baseline Characterization and a 12-Month Follow-Up Analysis
What features may predict bipolar disorder vs schizophrenia in a person with first-episode psychosis? In this journal CME activity, find out which tools could most aid diagnosis.
October 27, 2020
Do you talk with your patients with Parkinson disease about the burden of OFF episodes? Using assessment tools can spur communication. In this CME activity, follow along as 2 experts review the occurrence and identification of OFF time.
Randomized Controlled Trial of Riluzole Augmentation for Posttraumatic Stress Disorder: Efficacy of a Glutamatergic Modulator for Antidepressant-Resistant Symptoms
Current pharmacologic treatments for posttraumatic stress disorder (PTSD) have shown limited efficacy. This study investigated the efficacy of the glutamatergic modulator riluzole for combat-related PTSD symptoms resistant to SSRIs or SNRIs.
Despite substantial research on sex differences in adults with bipolar disorder, little is known about this topic in youth. This prospective study examined sex differences in mood symptomatology and psychiatric comorbidity in youth with bipolar disorder.
October 20, 2020
A Randomized, Placebo-Controlled Trial of Mirtazapine for the Treatment of Posttraumatic Stress Disorder in Veterans
Open trials and small controlled trials suggest mirtazapine is beneficial in treating posttraumatic stress disorder (PTSD). This randomized controlled trial study sought to determine the efficacy of mirtazapine monotherapy for PTSD.
Psychological and Coping Responses of Health Care Workers Toward Emerging Infectious Disease Outbreaks: A Rapid Review and Practical Implications for the COVID-19 Pandemic
When considering how to help health care workers cope with the effects of the COVID-19 crisis, what can be learned from the past? This review looked at psychological and coping responses used during the SARS, MERS, and Ebola outbreaks to see which were helpful.
October 13, 2020
This retrospective study explored whether 5 medications for PTSD with efficacy in meta-analyses of randomized controlled trials—fluoxetine, paroxetine, sertraline, topiramate, and venlafaxine—are also effective in routine clinical practice.
This double-blind, randomized, crossover study investigated the effects of a supratherapeutic dose of SPN-812, a drug currently under investigation as a treatment for ADHD, on cardiac repolarization (QTc) in healthy adults.
October 6, 2020
Real-World Preventive Effects of Suvorexant in Intensive Care Delirium: A Retrospective Cohort Study
Although previous studies have demonstrated the efficacy of suvorexant for delirium prevention in limited randomized clinical trial settings, this study aimed to examine the effects of suvorexant on delirium prevention in a real-world setting.
Prevalence of Passive Suicidal Ideation in the Early Stage of the Coronavirus Disease 2019 (COVID-19) Pandemic and Lockdown in a Large Spanish Sample
This study draws on an online survey conducted to determine the prevalence of passive suicidal ideation early in the COVID-19 pandemic in Spain. Read the report to learn about the risk factors and protective factors revealed by the study.
Read a full article on the basics of conducting meta-analysis. What it is, why it is necessary, and how to interpret a forest plot.
September 29, 2020
Read an article on how to reduce Tardive dyskinesia (TD) symptoms, including the use of the FDA-approved treatment options (valbenazine and deutetrabenazine).
Coprescribed Benzodiazepines in Older Adults Receiving Antidepressants for Anxiety and Depressive Disorders: Association With Treatment Outcomes
This analysis of data from 2 clinical trials examined the effect of benzodiazepines on outcomes in older patients with generalized anxiety disorder or major depressive disorder, including the likelihood of dropout, adherence, and treatment response.
Read a report on how the 1918-920 influenza pandemic in Taiwan impacted rates of suicide.
September 22, 2020