To what extent does religion play a role in attitudes toward health and disease among Arab-American Muslims? This study assessed the influence of religious beliefs on their attitudes toward mental illness, especially depression.
Have you ever wondered what criteria need to be satisfied before a patient can be involuntarily admitted to a psychiatric hospital? Read this article to explore the clinical, legal, and cultural considerations regarding this topic.
For preventing prescription drug misuse in young adults, it's important to know the source from which they obtained the drugs. This study used data from a large nationally representative sample to examine prescription drug misuse, drug sources, and substance use disorder in relation to educational status in US young adults.
This early report of 273 Hispanic patients with depression reveals how researchers were able to increase treatment engagement by using a targeted depression education intervention designed to help dispel myths about depression and its treatment. Read more to see if this method might work for your nonadherent patients.
Baclofen, a French Exception, Seriously Harms Alcohol Use Disorder Patients Without Benefit
To the Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1
First, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282; 320 patients, as with Bacloville), was negative (see Braillon et al2).
Second, Dr Andrade should have warned readers that Bacloville’s results are most questionable, lacking robustness. Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. Coincidentally (although as skeptics, we do not believe in coincidence), the initial statistical team was changed when data were sold to the French pharmaceutical company applying for the marketing authorization in France. As Ronald H. Coase warned, “If you torture the data long enough, it will confess.”