XAll Individual Users: You may have noticed, we have just launched our new website. We will be adding more features over the upcoming weeks that you will like, so there may be a few hiccups along the way. If this is your first time visiting since our relaunch, please reset your password so you can still access our journals and CME activities that we have been providing for over 80 years. If you have any questions or comments please contact us at webadmin@psychiatrist.com.
XAll Individual Users: You may have noticed, we have just launched our new website. We will be adding more features over the upcoming weeks that you will like, so there may be a few hiccups along the way. If this is your first time visiting since our relaunch, please reset your password so you can still access our journals and CME activities that we have been providing for over 80 years. If you have any questions or comments please contact us at webadmin@psychiatrist.com.
In this brief report, the authors evaluate the effects of a possible association between different bupropion formulations and treatment-emergent insomnia in veterans with major depressive disorder prescribed bupropion based on provider discretion.
Here, read about a 29-year-old woman who presented to our inpatient psychiatric facility for manic-like symptoms including pressured speech, flight of ideas, sexual preoccupations, and self-reported euphoria.
This report presents a case in which a visually impaired patient describes the development of visual hallucinations after 2 oral administrations of thiocolchicoside.
Serotonin syndrome appears in different gradations of severity, affecting recognition and reporting. Read this case report to find out more about this condition.
New-onset enuresis may be an underreported side effect of clozapine. The authors of this case report recommend directly questioning patients about clozapine-induced enuresis rather than vaguely inquiring about side effects.
Photophobia was once considered a rapidly reversible adverse effect of lithium mainly occurring in younger patients. This case describes a 50-year-old woman who experienced delayed-recovery lithium-induced photophobia and eye irritation with lithium.
Levetiracetam is often prescribed by neurologists. This report sheds light on the psychiatric sequelae associated with levetiracetam while highlighting clinical correlates and management issues.
Can lurasidone induce mania? Read about a patient who presented in a depressive episode with psychotic features who became acutely manic after starting lurasidone monotherapy.
Lithium neurotoxicity, both reversible and irreversible, can occur when lithium is combined with second-generation antipsychotics. Early detection and prompt management are needed. Do you know the causative factors?
Baclofen, a French Exception, Seriously Harms Alcohol Use Disorder Patients Without Benefit
To the Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1
First, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282; 320 patients, as with Bacloville), was negative (see Braillon et al2).
Second, Dr Andrade should have warned readers that Bacloville’s results are most questionable, lacking robustness. Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. Coincidentally (although as skeptics, we do not believe in coincidence), the initial statistical team was changed when data were sold to the French pharmaceutical company applying for the marketing authorization in France. As Ronald H. Coase warned, “If you torture the data long enough, it will confess.”