In this letter to the editor, Drs Grilo and Udo discuss a recent study that examined links between trauma, PTSD, and binge-eating symptoms; their perspective is set in the context of their own NESARC-based research on the topic.
Subthreshold posttraumatic stress disorder (PTSD) may lead to symptoms and functional impairment comparable to those of full PTSD. This study examined the burden of subthreshold PTSD in World Trade Center responders more than a decade after 9/11.
Leptin appears to have a relationship with PTSD, though the nature of the relationship is unclear. This study examined the prevalence and severity of PTSD among youth with different genotypes of leptin gene rs7799039 in the aftermath of an earthquake.
Trauma-exposed individuals engage in health-risk behaviors, though one such behavior—binge eating—is understudied in this population. This study evaluates the association between trauma exposure, posttraumatic stress disorder symptoms, and binge eating.
This article describes successful treatment of a patient with panic disorder and PTSD through script-driven trauma memory reactivation and inhalation of a xenon-based gas mixture. Read on to find out more about this promising treatment strategy.
Criminal justice populations report high rates of maltreatment during childhood. What specific childhood traumas lead to later arrest, incarceration, and delinquency? And can mentorship moderate these outcomes? Read this article to learn more.
US veterans are at a high risk of suicide, but what specific clinical factors are linked to this risk? This study of veterans discharged from PTSD programs examined the question in order to identify potential areas for preventive efforts.
History of childhood trauma and adult suicidal ideation are common in adults with schizophrenia. This study explored factors that may mediate between such trauma and ideation in patients with schizophrenia to help determine therapeutic approaches.
Here, read the case of a man admitted to the hospital in a manic state 15 years after suffering a traumatic brain injury. He had received several diagnoses over the past 2 years, including different iterations of bipolar disorder. His mania resolved after levodopa-carbidopa, which had been prescribed for an unsubstantiated diagnosis of Parkinson disease, was discontinued.
Although benzodiazepines can provide short-term relief for anxiety, their potential to worsen depression and suicidal thoughts potentially recommends against their use in patients with PTSD. Read this article to learn how use of these agents relates to health care utilization and suicide risk in PTSD patients.
PTSD symptoms have been documented in women following at-term deliveries with health baby outcomes. However, the notion that childbirth can trigger PTSD remains controversial, and the symptom clusters are mostly unknown. This study examined the clustering of childbirth-induced postpartum PTSD symptoms in comparison to DSM-5 clusters.
Baclofen, a French Exception, Seriously Harms Alcohol Use Disorder Patients Without Benefit
To the Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1
First, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282; 320 patients, as with Bacloville), was negative (see Braillon et al2).
Second, Dr Andrade should have warned readers that Bacloville’s results are most questionable, lacking robustness. Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. Coincidentally (although as skeptics, we do not believe in coincidence), the initial statistical team was changed when data were sold to the French pharmaceutical company applying for the marketing authorization in France. As Ronald H. Coase warned, “If you torture the data long enough, it will confess.”