Blood Clozapine Levels Elevated by Fluvoxamine: Potential for Side Effects and Lower Clozapine Dosage
J Clin Psychiatry 1997;58(11):499 [letter]
© Copyright 2014 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Letter to the Editor
Sir: We report a case in which very high blood clozapine
levels occurred during concomitant use of fluvoxamine. Previous
reports have indicated that close monitoring should be done
when these two medications are coprescribed because of
fluvoxamine’s ability to inhibit hepatic microsomal enzymes
that metabolize clozapine. However, on the basis of this case
and the microsomal enzyme profiles of these two medications,
we believe that extreme caution is warranted.