The Detection and Consequences of Anxiety in Clinical Depression

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Anxiety symptoms and comorbid anxiety are common in depressive syndromes, and there is evidence they are associated with increased severity of depression and a poorer outcome. Anxiety and agitation symptoms also appear to be an acute risk factor for suicide in patients who have major affective disorder, an observation that has been supported by a number of biological correlates. Rapid and aggressive treatment of these anxiety/agitation symptoms with suitable antidepressants or benzodiazepines should be considered in order to avoid the immediate risk of suicide and to permit successful treatment of the affective disorder.

J Clin Psychiatry 1997;58(suppl 8):35–40