Buspirone in the Management of Anxiety and Irritability in Children With Pervasive Developmental Disorders: Results of an Open-Label Study
J Clin Psychiatry 1998;59(2):56-59
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Background: We evaluated the efficacy and safety
of buspirone in the management of anxiety and irritability in
children with pervasive developmental disorders (PDD).
Method: Twenty-two subjects, 6 to 17 years old,
with DSM-III-R diagnosed PDD-NOS (N=20) or autistic disorder
(N=2), were included. They were treated with buspirone in dosages
ranging from 15 to 45 mg/day in an open-label trial lasting 6 to
8 weeks. Responders continued buspirone treatment and were
followed up for up to 12 months.
Results: Nine subjects had a marked therapeutic
response and 7 subjects a moderate response on the Clinical
Global Impressions (CGI) scale after 6 to 8 weeks of treatment.
Side effects were minimal, except for 1 patient who developed
abnormal involuntary movements.
Conclusion: These results suggest that buspirone
may be useful for treating symptoms of anxiety and irritability
in children with PDD.