Original Research
Original Research
CBT following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention: The CBT-ENDURE Randomized Trial
May 4, 2026
In patients with major depression and suicidal ideation, adding a 16-week CBT course to esketamine led to greater improvements in suicidal ideation and depression severity than esketamine alone.
Original Research
Phase 2b Study to Evaluate Basmisanil as Adjunctive Treatment in Patients With Cognitive Impairment Associated With Schizophrenia
April 15, 2026
Although basmisanil did not improve cognitive deficits, the results offer insight into factors that should facilitate design of more informative trials.
Original Research
Nonsuicidal Self-Injury and Its Association with Suicidal Ideation and Negative Affect
April 8, 2026
Desire to self-harm was associated with nonsuicidal self-injury (NSSI) episodes. Further, NSSI was related to higher negative affect and negative interpersonal experience, which decreased across follow-up.
Original Research
Using Natural Language Processing to Evaluate Differences in Psychotherapeutic Services for PTSD in a Suicide-Risk-Stratified Veteran Sample
April 8, 2026
Psychotherapeutic care for PTSD differed for patients who did and did not die by suicide, suggesting the importance of developing risk-tier-specific care.
Original Research
Correlates and Predictors of Criminal Legal Involvement in First-Episode Psychosis
March 30, 2026
More than 10% of people with first-episode psychosis are involved in the legal system before (11%) and while (14%) receiving mental health treatment, which can interrupt access to specialty...
Original Research
Neuropsychiatric Symptom Clusters and Brain Structure in Alzheimer’s Disease
March 16, 2026
Neuropsychiatric symptoms in Alzheimer’s disease separate into hyperactivity, psychosis, neurovegetative, and affective clusters, supporting a cluster-based paradigm linking behavioral symptoms with brain structure and functional decline.
Original Research
Safety and Efficacy of Maintenance Treatment with Aripiprazole Once-Monthly in Black/African American Adults With Bipolar I Disorder
March 9, 2026
The safety and efficacy of AOM 400 were comparable between Black/African American and non-Black/African American patients with bipolar I disorder
Original Research
Comparing Risk Prediction for Suicide Attempts and Deaths After Emergency Department Visits
March 4, 2026
Distinct factors predict nonfatal and fatal suicidal events. Male sex and depression are the strongest predictors for fatal events; being under 65 years of age and suicidal ideation are...
Original Research
Outcomes and Practice Patterns of LAI Versus Oral Antipsychotics Among Patients With Bipolar I Disorder in the US
March 2, 2026
Long-acting injectable antipsychotics, especially second-generation formulations, are associated with reduced rehospitalization in bipolar I disorder compared to oral antipsychotics.
Original Research
Validation of the APREMDI Scale for Brazilian Portuguese
February 19, 2026
The APREMDI scale allows clinicians to quantitatively assess patients’ perceptions of respect and dignity during hospitalization, helping to identify subtle dignity violations that may compromise recovery and satisfaction.
