Valproate Monotherapy in an SRI-Intolerant OCD Patient

Gabriela Corá-Locatelli, Benjamin D. Greenberg, Juliet D. Martin, and Dennis L. Murphy

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Sir: Many patients with obsessive-compulsive disorder (OCD) considered to be treatment refractory have prematurely discontinued serotonin reuptake inhibitors (SRIs) due to side effects (such as irritability and anxiety) and are not truly treatment refractory. Some OCD patients intolerant of SRIs had decreased adverse effects after pretreatment with valproic acid. We therefore pretreated an OCD patient intolerant of standard doses of fluoxetine, sertraline, and clomipramine with valproic acid.

J Clin Psychiatry 1998;59(2):82-82

© Copyright 1998 Physicians Postgraduate Press, Inc.