Weekly Mind Reader: What Do OCD and Pica Have In Common?

by Denis Storey
October 11, 2024 at 8:24 AM UTC

This week, we dig into a series of troubling case studies, unexpected side effects of the drug bupropion, and more bad news for Gen X.

This week covers OCD and self-harm, kids showing up in the ER with concurrent psychiatric conditions, and election anxiety.

Case Study Hints They Could Influence Self-Harm Behavior

A recent case study – appearing this week in The Primary Care Companion for CNS Disorders –  underscores the intricate interplay between obsessive-compulsive disorder (OCD) and pica.

A 34-year-old woman presented with severe self-harm obsessions and pica-like behavior. In addition to her anemia, she showed symptoms that included intense urges to bite hard objects, injure her eyes, and induce nosebleeds. Despite her best efforts, she typically surrendered to her urges, while craving constant encouragement from family members.

Caregivers originally administered fluoxetine, but it did little to alleviate her condition. Digging deeper, caregivers discovered she also had iron deficiency anemia, with a hemoglobin level of 8 g/dL. This prompted doctors to prescribe iron supplementation in conjunction with psychiatric treatment. Her compulsive behaviors fit the OCD profile, where patients succumb to compulsions as a result of intrusive fixations.

As treatment progressed, doctors bumped up her doses of fluoxetine, along with clomipramine and risperidone. Over the next eight weeks, her condition improved. Her Yale-Brown Obsessive-Compulsive Scale (YBOCS) score fell from 30 to 5, indicating an 80 percent reduction in symptoms. At the same time, her hemoglobin level improved to 10 g/dL.

This case underscores the often-overlooked link between OCD, pica, and iron deficiency. The woman’s self-harm obsessions and geophagia could be tied to her anemia, suggesting a need for a deeper investigation into the physiological links between nutritional deficiencies and OCD.

Treatment that pairs selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and antipsychotic medications proved effective in managing her symptoms, offering insight into potential therapeutic approaches for similar cases.

IN OTHER PSYCHIATRY AND NEUROLOGY NEWS

  • Data analysis reveals that nearly 39 percent of kids who arrive in the emergency room show up with a concurrent psychiatric diagnosis, highlighting the importance of a holistic psychiatric care approach.
  • The upcoming election is putting a strain on the mental health of many Americans, particularly younger voters and women.
  • Readers write to PCC to discuss which AI modality has the most potential to help a patient with delusional parasitosis based on the Empathy Scale for Human-Computer Communication score.
  • EMERGENT trials showed the newly approved xanomeline-trospium (Cobenfy) offers benefits and fewer side effects than older schizophrenia drugs.
  • Finally, read the latest in our ongoing series covering PTSD and trauma research.

Original Research

Long-Term Safety, Tolerability, and Durability of Treatment Effect of Olanzapine and Samidorphan: Results of a 4-Year Open-Label Study

During up to 4 years of treatment, the combination of olanzapine/samidorphan was safe and well-tolerated, and patients’ symptoms remained stable.

Jacob S. Ballon and others

Original Research

Evolution of Treatment Modalities for Posttraumatic Stress Disorder: Top 100 Cited Articles From 1990 to 2020

The authors provide a bibliometric analysis of the most-cited articles published from 1990 to 2020 on evidence-based treatment modalities for PTSD to highlight significant developments in its understanding and management.

Mohsan Ali and others