Medication Compliance Among Patients With Bipolar Disorder and Substance Use Disorder
J Clin Psychiatry 1998;59:172-174
© Copyright 2014 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: This study examined patterns of
medication compliance and reasons for noncompliance among
patients with bipolar disorder and substance use disorder.
Method: Forty-four patients with current bipolar
disorder and substance use disorder were administered a
structured interview regarding lifetime compliance with
prescribed psychotropic medications.
Results: Patients who were prescribed both
lithium and valproate were significantly (p=.03) more likely to
report full compliance with valproate than with lithium. Side
effects were the most common reason for lithium noncompliance,
but were not cited as a reason for valproate noncompliance. Also,
a common pattern of noncompliance among patients prescribed
benzodiazepines, neuroleptics, and tricyclic antidepressants was
the use of more medication than prescribed.
Conclusion: Valproate may have greater
acceptability than lithium among patients with bipolar disorder
and substance use disorder. Clinicians should also be aware that
these patients may take higher doses of medication than