Gabapentin Treatment of Mood Disorders: A Preliminary Study
J Clin Psychiatry 1998;59(8):426-429
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Objective: To determine if gabapentin is effective either as adjunctive
treatment or as monotherapy for major affective disorders in a naturalistic setting.
Method: All charts of patients meeting DSM-IV criteria for bipolar
disorder or unipolar major depressive disorder treated with gabapentin in a private
psychiatric practice were reviewed and clinical response was assessed retrospectively
using the Clinical Global Impressions scale for Improvement (CGI-I).
Results: Gabapentin was moderately to markedly effective in 30% (15/50)
of patients, with statistically nonsignificant differences between patients with bipolar
disorder type I, bipolar disorder type II and NOS, and unipolar major depressive disorder.
70% reported side effects, mainly sedation, with 16% of the total sample discontinuing
treatment due to adverse events.
Conclusion: Gabapentin appears to be somewhat effective as add-on
treatment in a subgroup of patients with mood disorders in a naturalistic setting.
Prospective, controlled studies are required to clarify these pilot data.