A Large Open-Label Study of Venlafaxine in Depressed Outpatients by Community-Based Physicians
J Clin Psychiatry 1998;59(10):515-520
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: Studies to date suggest that venlafaxine is effective, well
tolerated, and safe in a broad spectrum of patients. We examined the clinical utility and
tolerability of venlafaxine in patients treated by community-based psychiatrists and
family physicians in a naturalistic clinical setting.
Method: Nineteen physicians each recruited 10 to 20 physicians to enroll
5 patients each maximum, diagnosed with DSM-IV major depression or dysthymia. The patients
were at least moderately ill (Clinical Global Impressions) with a score of at least 32 on
the Zung Self-Rating Depression Scale. After baseline clinical and laboratory assessments,
each patient received 37.5 mg of venlafaxine b.i.d., with adjustments possible at the 5
visits during the next 8 weeks.
Results: Of the 880 patients at baseline, 682 completed the 8-week study.
The daily doses of venlafaxine ranged between 18.75 mg and 375 mg, with 80% receiving
between 75 and 150 mg/day by 8 weeks. The intent-to-treat analysis revealed that at 8
weeks, 62% (522 of 843) of patients were either much or very much improved. Nausea was the
most frequent side effect, followed by somnolence, headache, and dry mouth.
Conclusion: Venlafaxine has good clinical utility and tolerability in a
community-based sample of a broad spectrum of depressed outpatients.