Olanzapine Treatment After Clozapine-Induced Granulocytopenia in 3 Patients
J Clin Psychiatry 1999;60(2):119-121
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Background:How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.
Case reports: We report 3 patients with chronic schizophrenia who had previously stopped clozapine due to hematologic side effects. The patients evidenced improvement with olanzapine that equated to 16- to 31-point decreases in rating scale scores during 1-year follow-up without any hematologic abnormalities.
Conclusion: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.