Valproate-Induced Hyperammonemia in the Psychiatric Setting: 2 Cases

View This PDF

NB: This article is only available as a PDF.

Letter to the Editor

Sir: Although several case reports have described valproate induced reversible elevation of serum ammonia levels, this problem may not be recognized quickly owing to lack of sufficient awareness. A high level of suspicion will enable the busy clinician to identify and intervene promptly in this clinical setting. This is particularly relevant in today’s clinical psychiatric practice owing to the current widespread use of valproate in the acute and maintenance treatment of psychiatric disorders.

J Clin Psychiatry 1999;60(8):557-559