A Placebo-Controlled Trial of Cognitive-Behavioral Therapy and Clomipramine in Trichotillomania
J Clin Psychiatry 2000;61(1):47-50
© Copyright 2014 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: The major treatments reported
to be effective in the treatment of trichotillomania are
cognitive-behavioral therapy (CBT) with habit reversal and
serotonin-norepinephrine reuptake inhibitors such as
clomipramine. However, the 2 treatments have not been previously
compared with each other. This study examines the efficacy of CBT
and clomipramine compared with placebo in the treatment of
Method: Twenty-three patients with
trichotillomania as determined by the Structured Clinical
Interview for DSM-III-R entered and 16 completed a 9-week,
placebo-controlled, randomized, parallel-treatment study of CBT
and clomipramine. Efficacy was evaluated by the Trichotillomania
Severity Scale, the Trichotillomania Impairment Scale, and the
Clinical Global Impressions-Improvement scale, which were
conducted by an independent assessor blinded to the treatment
Results: CBT had a dramatic effect in
reducing symptoms of trichotillomania and was significantly more
effective than clomipramine (p = .016) or placebo (p = .026).
Clomipramine resulted in symptom reduction greater than that with
placebo, but the difference fell short of statistical
significance. Placebo response was minimal.
Conclusion: Clinicians should be aware of
the potential treatments available for trichotillomania. A larger
and more definitive study comparing CBT and a
serotonin-norepinephrine reuptake inhibitor is indicated.