Weight Gain With Risperidone Among Patients With Mental Retardation: Effect of Calorie Restriction
J Clin Psychiatry 2001;62(2):114-116
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Background: The atypical antipsychotics cause
weight gain, which is poorly understood in terms of its mechanism
and treatment. A usual recommendation for treatment of
antipsychotic-induced weight gain includes calorie restriction
and exercise. The authors describe their recent clinical
experience with calorie restriction in adults with mental
retardation treated with risperidone.
Method: A retrospective chart review was
performed on the records of 50 adult patients with mental
retardation treated with risperidone while residing at a
habilitation center. We assessed dose and duration of risperidone
treatment, weight, changes in calorie intake, and frequency of
Results: Of the 50 patients, 39 had adequate
data for analysis. Thirty-seven of the 39 patients gained weight
with a mean of 18.8 lb (8.3 kg) over about 2 years. Twenty of the
37 patients were calorie restricted. Three of the 20
calorie-restricted patients lost weight at a rate of 0.2 lb (0.1
kg) per month. The other 17 calorie-restricted patients and the
17 patients who were not calorie restricted continued to gain
weight at a rate of 0.8 lb (0.4 kg) per month over about another
2 years of treatment. The amount of weight gain was not dose
related. Calorie restriction led to no deterioration in behavior.
Conclusion: The current investigation lends
support to data that note weight gain with risperidone in adults
with mental retardation. It suggests that calorie restriction
does not lead to weight loss or behavioral deterioration and that
weight gain is not dose related.