Weight Gain With Risperidone Among Patients With Mental Retardation: Effect of Calorie Restriction
J Clin Psychiatry 2001;62:114-116
© Copyright 2014 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: The atypical antipsychotics cause
weight gain, which is poorly understood in terms of its mechanism
and treatment. A usual recommendation for treatment of
antipsychotic-induced weight gain includes calorie restriction
and exercise. The authors describe their recent clinical
experience with calorie restriction in adults with mental
retardation treated with risperidone.
Method: A retrospective chart review was
performed on the records of 50 adult patients with mental
retardation treated with risperidone while residing at a
habilitation center. We assessed dose and duration of risperidone
treatment, weight, changes in calorie intake, and frequency of
Results: Of the 50 patients, 39 had adequate
data for analysis. Thirty-seven of the 39 patients gained weight
with a mean of 18.8 lb (8.3 kg) over about 2 years. Twenty of the
37 patients were calorie restricted. Three of the 20
calorie-restricted patients lost weight at a rate of 0.2 lb (0.1
kg) per month. The other 17 calorie-restricted patients and the
17 patients who were not calorie restricted continued to gain
weight at a rate of 0.8 lb (0.4 kg) per month over about another
2 years of treatment. The amount of weight gain was not dose
related. Calorie restriction led to no deterioration in behavior.
Conclusion: The current investigation lends
support to data that note weight gain with risperidone in adults
with mental retardation. It suggests that calorie restriction
does not lead to weight loss or behavioral deterioration and that
weight gain is not dose related.