Anxiety Disorders Following Miscarriage
J Clin Psychiatry 2001;62:432-438
© Copyright 2014 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: Several previous studies have
established that miscarriage is a risk factor for depressive
symptoms and disorder. By contrast, research on miscarriage as a
possible risk factor for anxiety symptoms is inconclusive, and
for anxiety disorders, sparse and uninformative. The current
study examines the incidence of and relative risk for 3 DSM-III
anxiety disorders (obsessive-compulsive disorder [OCD], panic
disorder, and phobic disorders) within the 6 months following
miscarriage. Adequate diagnostic data on other anxiety disorders
were not available.
Method: Using a cohort design, we tested whether
women who miscarry are at increased risk for a first or recurrent
episode of an anxiety disorder in the 6 months following loss.
The miscarriage cohort consisted of women attending a medical
center for spontaneous abortion (N = 229); the comparison group
was a population-based cohort of women drawn from the community
(N = 230).
Results: Among miscarrying women, 3.5%
experienced a recurrent episode of OCD, compared with 0.4% of
community women (relative risk [RR] = 8.0; 95% confidence
interval [CI] = 1.0 to 63.7). The relative risk for noncomorbid
panic disorder was substantial (RR = 3.6), albeit not
statistically significant (95% CI = 0.8 to 17.2). There was no
strong evidence for increased risk for phobic disorders or
agoraphobia, combined or considered separately, in the 6 months
following loss. Relative risk for all 3 disorders combined was
1.5 (95% CI = 0.9 to 2.3).
Conclusion: In this first miscarriage cohort
study using a concurrent frequency-matched comparison group,
miscarriage was a substantial risk factor for an initial or
recurrent episode of OCD. Given statistical power limitations of
this investigation, the current findings do not preclude a
possible contribution of miscarriage to risk for other anxiety