Comparison of Sexual Dysfunction in Male Schizophrenic Patients Maintained on Treatment With Classical Antipsychotics Versus Clozapine
J Clin Psychiatry 2001;62(7):541-544
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Background: Antipsychotic treatment is
frequently associated with sexual dysfunction. The objective of
the present study was to evaluate and compare sexual function and
behavior in male schizophrenic patients who regularly take either
classical neuroleptic drugs or the prototypical atypical
antipsychotic agent, clozapine.
Method: Participants included 60 schizophrenic
male patients (DSM-IV criteria); 30 maintained on treatment with
classical antipsychotics and 30 on treatment with clozapine. The
patients were evaluated with a detailed 18-item sexual function
Results: Both groups reported sexual
dysfunction, although scores were significantly higher,
indicating better functioning, in the clozapine-treated group in
the domains of orgasmic function (number of orgasms per month, p
= .037; frequency of orgasm during sex, p = .046), enjoyment of
sex (p = .013), and sexual satisfaction (p = .0004). Equivocal
results were obtained for the desire parameters.
Conclusion: Maintenance therapy with the
atypical neuroleptic clozapine may be associated with a lesser
degree of sexual dysfunction than the classical antipsychotics in
male outpatients with chronic schizophrenia.