Cognitive-Behavioral Management of Patients With Bipolar Disorder Who Relapsed While on Lithium Prophylaxis
J Clin Psychiatry 2001;62(7):556-559
© Copyright 2015 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: The application of
cognitive-behavioral treatment (CBT) to patients with bipolar
disorder who had an affective episode while on lithium
prophylaxis has received little research attention. The aim of
this preliminary study was to test whether reduction of residual
symptomatology by cognitive-behavioral methods could yield
long-term beneficial effects in patients with bipolar disorder,
as was found to be the case in recurrent unipolar depression.
Method: Fifteen patients with RDC bipolar
disorder, type I, who relapsed while on lithium prophylaxis
despite initial response and adequate compliance were treated by
cognitive-behavioral methods in an open trial. A 2- to 9-year
follow-up was performed.
Results: Five of the 15 patients had a new
affective episode during follow-up. CBT was associated with a
significant reduction of residual symptomatology.
Conclusion: These preliminary results suggest
that a trial of CBT may enhance lithium prophylaxis and improve
long-term outcome of bipolar disorder.