Selecting Methodologies for the Evaluation of Differences in Time to Response Between Antidepressants.[CME]
J Clin Psychiatry 2002;63(8):694-699
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: The delay in the
therapeutic effect of antidepressants is a considerable
impediment to their successful clinical use, and
attention has recently been focused on antidepressant
drugs that may have a faster onset of action.
Data Synthesis: Several methodologies
exist for evaluating differences in time to response
between antidepressants including the
identification of the timepoint at which statistically or
clinically significant differences between treatment
groups emerge, pattern analysis, and survival
analytical approaches. All have conceptual as well as
practical advantages and disadvantages.
Conclusion: The survival analytical
approach is generally considered to be the most
rigorous and sensitive in detecting differences in the
speed of response of antidepressants, but the
other methodologies provide useful information.