Citalopram for Compulsive Shopping Disorder: An Open-Label Study Followed by Double-Blind Discontinuation
J Clin Psychiatry 2003;64(7):793-798
© Copyright 2017 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: Open-label trials suggested that
fluvoxamine and citalopram may be effective for compulsive
shopping disorder, but 2 double-blind fluvoxamine trials failed
to confirm this. To test the hypothesis that citalopram is a
safe, effective treatment for this disorder, we conducted a
7-week, open-label trial followed by a 9-week, double-blind,
placebo-controlled discontinuation trial.
Method: From Jan. 2001 to Jan. 2002, we enrolled
adult outpatients meeting diagnostic criteria suggested in a
prior study for compulsive shopping disorder and having a score
of >= 17 on the Yale-Brown Obsessive Compulsive Scale-Shopping
Version (YBOCS-SV). Open-label citalopram was started at 20
mg/day and increased, absent marked response and limiting side
effects, to 60 mg/day. Responders (subjects rated "much
improved" or "very much improved" on the Clinical
Global Impressions-Improvement scale [CGI-I] and having a >=
50% decrease in YBOCS-SV score) were randomized to double-blind
citalopram treatment at the week 7 dose or placebo for 9 weeks.
Results: We enrolled 24 subjects (23
women and 1 man). Mean ± SD YBOCS-SV scores decreased
significantly from 24.3 ± 4.6 at baseline to 8.2 ± 8.1 at week
7 (Wilcoxon signed rank: z = 4.20, p < .001). Fifteen of 24
subjects (63%) met the responder criteria. Three subjects (13%)
discontinued for adverse events (1 each for headache, rash, and
insomnia). Of the 15 responders who entered the double-blind
treatment phase, 5 of 8 (63%) randomized to placebo relapsed
(YBOCS-SV score >= 17 and "minimally improved" or
less on the CGI-I) compared with none of 7 randomized to continue
taking citalopram (Fisher exact test p = .019).
Conclusion: Citalopram appears to be a safe and
effective treatment for compulsive shopping disorder. Further
trials of citalopram and other selective serotonin reuptake
inhibitors are warranted.