Negative Symptoms in Depressed and Schizophrenic Patients: How Do They Differ?
J Clin Psychiatry 2003;64(8):954-958
© Copyright 2017 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: The present study evaluated
differences in negative symptoms between schizophrenic and
depressive patients and investigated whether a consideration of
the nature of negative symptoms (enduring vs. nonenduring) can
help to improve their specificity for schizophrenia.
Method: Patients enrolled in the study were
consecutively hospitalized with an acute exacerbation of
schizophrenia (N = 33) or major depressive disorder (N = 43)
(DSM-IV). Negative and depressive symptoms were assessed with the
Scale for the Assessment of Negative Symptoms (SANS) and the
Montgomery-Asberg Depression Rating Scale, respectively. Duration
of negative symptoms was assessed through a semistructured
interview with the patients and their closest relatives. On the
basis of the assessed duration of symptoms, negative symptoms
were categorized as enduring or nonenduring.
Results: Analyses revealed high SANS ratings for
both diagnostic groups. Negative symptoms in depressive patients
(p = .01), but not in schizophrenic patients, were significantly
associated with the presence or the emergence of depressive
symptoms. The prevalence of enduring negative symptoms was
significantly higher in schizophrenic patients than in depressive
patients (p < .01). A consideration of enduring negative
symptoms significantly increased the discriminative power of
negative symptoms for schizophrenia (p = .02).
Conclusion: The present findings suggest that
negative symptoms in most depressive patients are just an
epiphenomenon of depressive symptoms and can be distinguished
from schizophrenic negative symptoms.