Pilot Trial of Ondansetron in the Treatment of 8 Patients With Obsessive-Compulsive Disorder
J Clin Psychiatry 2003;64:1025-1030
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Method: Eight medication-free subjects
with a DSM-IV diagnosis of OCD and a Yale-Brown Obsessive
Compulsive Scale (YBOCS) score >= 16 entered an 8-week
open-label trial of ondansetron at a fixed dose of 1 mg 3 times
daily in a study conducted between February and October 1998.
Results: Six subjects completed the
trial. Three subjects (37%) achieved a clinically significant
response (>= 35% reduction in YBOCS score). For these
subjects, the average reduction in YBOCS-rated symptoms was 55%.
In aggregate, the 8 patients exhibited a 28% reduction in
YBOCS-rated symptoms over the course of the trial. The medication
was well tolerated.
Conclusion: These results suggest that
low-dose ondansetron may have promise as a monotherapy for some
patients suffering from OCD.