High-Dose Olanzapine and Prolactin Levels
J Clin Psychiatry 2003;64(10):1192-1194
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: This study evaluates whether
high-dose olanzapine is associated with elevation of serum
Method: Twenty-four patients taking daily doses
of olanzapine of 20, 25, 30, and 40 mg for DSM-IV schizophrenia
or schizoaffective disorder had serum prolactin levels measured.
The patients were all from one author's (J.L.K.'s) clinical
practice. The mean duration of olanzapine therapy was 15.3 months
at a dose of at least 20 mg/day. Data were gathered in 2000 and
Results: There was no significant correlation
between olanzapine dose and prolactin level (Pearson product
moment correlation coefficient = 0.09). No significant
differences were found between mean prolactin values in each dose
Conclusion: There was no significant elevation
of prolactin with higher doses of olanzapine. Thus, preliminary
evidence suggests that using higher doses of olanzapine is
generally safe with regard to prolactin levels.