High-Dose Olanzapine and Prolactin Levels
J Clin Psychiatry 2003;64(10):1192-1194
© Copyright 2015 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: This study evaluates whether
high-dose olanzapine is associated with elevation of serum
Method: Twenty-four patients taking daily doses
of olanzapine of 20, 25, 30, and 40 mg for DSM-IV schizophrenia
or schizoaffective disorder had serum prolactin levels measured.
The patients were all from one author's (J.L.K.'s) clinical
practice. The mean duration of olanzapine therapy was 15.3 months
at a dose of at least 20 mg/day. Data were gathered in 2000 and
Results: There was no significant correlation
between olanzapine dose and prolactin level (Pearson product
moment correlation coefficient = 0.09). No significant
differences were found between mean prolactin values in each dose
Conclusion: There was no significant elevation
of prolactin with higher doses of olanzapine. Thus, preliminary
evidence suggests that using higher doses of olanzapine is
generally safe with regard to prolactin levels.