Anxiety Symptoms and Quality of Life in Middle-Aged and Older Outpatients With Schizophrenia and Schizoaffective Disorder
J Clin Psychiatry 2003;64(12):1476-1482
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Objective: This study examined whether anxiety
symptoms make an independent contribution to poorer quality of
life among middle-aged and older outpatients with schizophrenia
or schizoaffective disorder.
Method: We evaluated data from an ongoing study
of 163 older patients with DSM-III-R or DSM-IV schizophrenia or
schizoaffective disorder who were enrolled in research at the
University of California, San Diego, Advanced Center for
Interventions and Services Research from October 1992 to April
1998. Measures used were the anxiety, somatization,
obsessive-compulsive, and phobic anxiety subscales of the Brief
Symptom Inventory. We performed hierarchical multiple regressions
with forced entry of variables to determine whether anxiety
symptoms significantly predicted poorer health-related quality of
life (measured by 2 scales) after controlling for demographic
variables, akathisia, cognitive impairment, depressive symptoms,
and overall psychopathology.
Results: Anxiety symptoms were associated with
poorer outcomes on overall quality of well-being and subscales
representing vitality, social functioning, and role functioning
limitations due to physical problems. In most cases, the
proportion of variance in quality of life accounted for by
anxiety symptoms was greater than that accounted for by
Conclusions: Results suggest that anxiety
symptoms have a significant negative impact on the quality of
life of middle-aged and older patients with schizophrenia and