Prevalence of Obsessive-Compulsive Disorder in Patients With Systemic Lupus Erythematosus
J Clin Psychiatry 2004;65:301-306
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: The goal of this pilot study was to
investigate the prevalence of obsessive-compulsive disorder (OCD)
in a group of patients with systemic lupus erythematosus (SLE).
Method: Fifty adult patients enrolled in
outpatient SLE studies at the National Institute of Arthritis and
Musculoskeletal and Skin Diseases (February 1995-October 1996)
completed a self-report questionnaire adapted from the Yale-Brown
Obsessive Compulsive Scale and an in-person psychiatric clinical
interview with a psychiatrist or psychiatric clinical nurse
specialist. DSM-IV lifetime diagnosis of OCD was determined by
Results: Sixteen subjects (32%) met DSM-IV
lifetime diagnostic criteria for OCD and an additional 5
(10%) met criteria for subclinical OCD. Mean ± SD number of
symptoms reported on the self-report questionnaire was
significantly higher among subjects diagnosed with OCD on
clinical interview (40.7 ± 23.2) compared with those without OCD
(8.9 ± 11.7; t = 5.8, df = 27, p < .001).
Conclusion: Obsessive-compulsive disorder was 10
to 15 times more common in this cohort of patients with SLE
compared with those in community-based studies of OCD. The use of
an OCD self-report rating scale proved helpful in the
identification of OCD symptoms among patients with SLE. Results
suggest that further studies of OCD in patients with SLE are
needed and may provide new insight into the pathophysiology of