A 3-Month, Follow-Up, Randomized, Placebo-Controlled Study of Repetitive Transcranial Magnetic Stimulation in Depression
J Clin Psychiatry 2004;65(10):1323-1328
© Copyright 2014 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background/Objective: There is evidence for an antidepressant effect of repetitive transcranial magnetic stimulation (rTMS) but little is known about posttreatment course. Therefore we conducted a placebo-controlled double-blind study in depressed patients in order to investigate the effect of rTMS on depression over 12 weeks after completion of the 2-week stimulation period.
Method: 55 patients with a moderate or severe DSM-IV major depressive episode were randomly assigned to rTMS or sham treatment. rTMS was given daily for 10 days over the left dorsolateral prefrontal cortex with the following treatment parameters: 20 Hz 20 trains of 2 seconds 30 seconds between trains and 80% motor threshold. The effect of rTMS on depression was rated repeatedly with the 17-item Hamilton Rating Scale for Depression (HAM-D) during the 2-week period of stimulation and the 12-week follow-up period conducted from 1997 to 2001.
Results: We found a modest clinically nonrelevant decrease in HAM-D scores in both rTMS and sham patients over 2 weeks of treatment. However over the subsequent 12-week follow-up the rTMS group continued to improve significantly compared with the placebo group.
Conclusion: Decrease of depressive symptoms may continue after the cessation of rTMS stimulation.